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Table 5 SEQ Scores

From: An exploratory, randomised, crossover study to investigate the effect of nicotine on cognitive function in healthy adult smokers who use an electronic cigarette after a period of smoking abstinence

 

Test product

Reference product

LSMean (95% CI)

Difference in LSMeans (95% CI) Test—Reference

Tukey

Adjusted

P-value

Cohen’s d effect size

Test product

Reference product

Positive Emotion Score

EPEN-0 mg (n = 38)

No Product (n = 37)

5.4

(0.7, 10.2)

− 0.9

(− 5.8, 4.0)

6.4

(− 1.5, 14.2)

0.1743

0.52

EPEN-12 mg (n = 39)

No Product (n = 37)

8.0

(3.3, 12.8)

− 0.9

(− 5.8, 4.0)

8.9

(1.0, 16.9)

0.0190*

0.73

EPEN-18 mg (n = 39)

No Product (n = 37)

11.1

(6.4, 15.8)

− 0.9

(− 5.8, 4.0)

12.0

(4.1, 19.9)

0.0004*

0.98

Combustible Cigarette (n = 39)

No Product (n = 37)

12.0

(7.2, 16.7)

− 0.9

(− 5.8, 4.0)

12.9

(4.9, 20.8)

0.0001*

1.05

EPEN-12 mg (n = 39)

EPEN-0 mg (n = 38)

8.0

(3.3, 12.8)

5.4

(0.7, 10.2)

2.6

(− 5.2, 10.4)

0.8919

0.21

EPEN-18 mg (n = 39)

EPEN-0 mg (n = 38)

11.1

(6.4, 15.8)

5.4

(0.7, 10.2)

5.7

(− 2.1, 13.5)

0.2693

0.46

Combustible Cigarette (n = 39)

EPEN-0 mg (n = 38)

12.0

(7.2, 16.7)

5.4

(0.7, 10.2)

6.5

(− 1.3, 14.3)

0.1506

0.53

EPEN-18 mg (n = 39)

EPEN-12 mg (n = 39)

11.1

(6.4, 15.8)

8.0

(3.3, 12.8)

3.1

(− 4.6, 10.8)

0.8029

0.25

Combustible Cigarette (n = 39)

EPEN-12 mg (n = 39)

12.0

(7.2, 16.7)

8.0

(3.3, 12.8)

3.9

(− 3.8, 11.7)

0.6222

0.32

Combustible Cigarette (n = 39)

EPEN-18 mg (n = 39)

12.0

(7.2, 16.7)

11.1

(6.4, 15.8)

0.8

(− 6.8, 8.5)

0.9981

0.07

Negative Emotion Score

EPEN-0 mg (n = 38)

No Product (n = 37)

− 6.3

(− 11.0, − 1.7)

− 1.4

(− 6.2, 3.4)

− 5.0

(− 12.7, 2.8)

0.3997

0.41

EPEN-12 mg (n = 39)

No Product (n = 37)

− 10.0

(− 14.7, − 5.4)

− 1.4

(− 6.2, 3.4)

− 8.7

(− 16.5, − 0.8)

0.0220*

0.71

EPEN-18 mg (n = 39)

No Product (n = 37)

− 11.8

(− 16.4, − 7.2)

− 1.4

(− 6.2, 3.4)

− 10.4

(− 18.2, − 2.6)

0.0028*

0.86

Combustible Cigarette (n = 39)

No Product (n = 37)

− 13.1

(− 17.8, − 8.5)

− 1.4

(− 6.2, 3.4)

− 11.8

(− 19.6, − 3.9)

0.0005*

0.97

EPEN-12 mg (n = 39)

EPEN-0 mg (n = 38)

− 10.0

(− 14.7, − 5.4)

− 6.3

(− 11.0, − 1.7)

− 3.7

(− 11.4, 4.0)

0.6714

0.31

EPEN-18 mg (n = 39)

EPEN-0 mg (n = 38)

− 11.8

(− 16.4, − 7.2)

− 6.3

(− 11.0, − 1.7)

− 5.5

(− 13.1, 2.2)

0.2891

0.45

Combustible Cigarette (n = 39)

EPEN-0 mg (n = 38)

− 13.1

(− 17.8, − 8.5)

− 6.3

(− 11.0, − 1.7)

− 6.8

(− 14.5, 0.9)

0.1109

0.56

EPEN-18 mg (n = 39)

EPEN-12 mg (n = 39)

− 11.8

(− 16.4, − 7.2)

− 10.0

(− 14.7, − 5.4)

− 1.8

(− 9.4, 5.9)

0.9687

0.15

Combustible Cigarette (n = 39)

EPEN-12 mg (n = 39)

− 13.1

(− 17.8, − 8.5)

− 10.0

(− 14.7, − 5.4)

− 3.1

(− 10.7, 4.5)

0.7936

0.26

Combustible Cigarette (n = 39)

EPEN-18 mg (n = 39)

− 13.1

(− 17.8, − 8.5)

− 11.8

(− 16.4, − 7.2)

− 1.3

(− 8.9, 6.3)

0.9884

0.11

  1. Results obtained using an ANCOVA with fixed effects of product, period, sequence and a random effect of subject nested within sequence with the baseline value as a covariate (*indicates p =  < 0.05). Baseline defined as Pre-IP Use.