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Table 1 Example of flexibility in IOT prescription

From: Methodology for the Randomised Injecting Opioid Treatment Trial (RIOTT): evaluating injectable methadone and injectable heroin treatment versus optimised oral methadone treatment in the UK

  Drug & route Dose & time
Regime A Diamorphine (IV or IM)
Diamorphine (IV or IM)
Methadone (oral)
200 mg morning
200 mg afternoon
30 mg evening
Regime B Diamorphine (IV or IM)
Methadone (oral)
200 mg (daily)
100 mg (daily)
Regime C Methadone (oral) 160 mg