Methodology for the Randomised Injecting Opioid Treatment Trial (RIOTT): evaluating injectable methadone and injectable heroin treatment versus optimised oral methadone treatment in the UK

Table 1 Example of flexibility in IOT prescription

	Drug & route	Dose & time
Regime A	Diamorphine (IV or IM) Diamorphine (IV or IM) Methadone (oral)	200 mg morning 200 mg afternoon 30 mg evening
Regime B	Diamorphine (IV or IM) Methadone (oral)	200 mg (daily) 100 mg (daily)
Regime C	Methadone (oral)	160 mg