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Table 1 Recovery of morphine after cold extraction and filtration

From: Effect of filtration on morphine and particle content of injections prepared from slow-release oral morphine tablets

Filtration Volume of extract
(ml)
Amount of morphine
(mg)
P versus cig.
filter alone*
None 3.0 55.8 ± 1.9
(N = 4)
 
Cigarette filter    
First filtrate 1.7 ± 0.1 31.7 ± 2.3  
First rinse 1.1 ± 0.0 12.8 ± 0.7  
Second rinse 1.1 ± 0.1 5.9 ± 0.2  
Total 3.9 ± 0.1 50.5 ± 1.8  
Cotton wool    
First filtrate 1.7 ± 0.1 30.5 ± 1.9  
First rinse 1.1 ± 0.1 10.6 ± 1.2  
Second rinse 1.0 ± 0.0 5.0 ± 0.8  
Total 3.8 ± 0.0 46.1 ± 0.1 0.099
0.45 μm filter 1.9 ± 0.0 33.9 ± 1.0 0.098
Combined filtration    
Cig.+ 0.45 μm filter 5.0 ± 0.2 51.5 ± 0.7 0.701
Cig. + 0.22 μm filter 4.9 ± 0.2 51.9 ± 1.4 0.410
  1. Data are mean ± SD, N = 3 except where otherwise indicated.
  2. *This figure provides a comparison of the amount of morphine recovered through use of the target filter to that recovered through use of a cigarette filter. Comparisons were made by Mann-Whitney U test (a non-parametric analogue of the t-test), 2-tailed. Results are consistent with parametric analysis with Games-Howell post-hoc tests with the exception of 0.45 μm filters (p < 0.05). P values greater than 0.05 suggest that it is unlikely that there is any real difference between the amount of morphine recovered in the two compared techniques.