Parameter* | Morphine N = 27 | Morphine + Naltrexone N = 27 | Placebo N = 26 |
---|---|---|---|
TEmax, h, median (range) | 1.0 (0.3, 8.0) | 5.0 (0.1, 12.0) | 2.0 (0.0, 24.0) |
Emax, mm Hg | 47.1 (45.7, 48.5)a | 42.9 (41.5, 44.3)b | 41.9 (40.5, 43.3) |
AUE0-2 (h•mm Hg) | 11.1 (8.8, 13.5)a | 4.8 (2.4, 7.1)a,b | 1.6 (-0.8, 4.0) |
AUE0-8 (h•mm Hg) | 42.7 (33.0, 52.3)a | 21.1 (11.5, 30.8)a,b | 4.6 (-5.2, 14.5) |
AUE0-24 (h•mm Hg) | 96.3 (63.3, 129.3)a | 74.6 (41.6, 107.6)a | 11.8 (-21.9, 45.4) |