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Fig. 1 | Harm Reduction Journal

Fig. 1

From: The effects of heat and freeze-thaw cycling on naloxone stability

Fig. 1

Naloxone hydrochloride maintains chemical stability following exposure to heat and freeze-thaw cycles. a Naloxone hydrochloride ampoules were exposed to 80 °C for 8 h daily followed by 16 h at room temperature, or b − 20 °C for 16 h daily followed 4 °C for 8 h for up to 28 days. Naloxone hydrochloride concentration was determined using HPLC at 282 nm and a calibration plot generated using a naloxone hydrochloride reference standard. Ampoules were exposed for the following number of days: 0, 1, 2, 3, 4, 5, 6, 7, 14, and 28. Naloxone ampoules stored at room temperature served as the experimental control (exposure of zero days)

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