Fig. 2

Degradation of the parabens correlates with duration of exposure to heat. The preserving agents found in naloxone ampoules are the parabens (methylparaben and propylparaben). a Chromatograms obtained from HPLC at 282 nm revealed an additional peak that increased in intensity (evaluated as area under the curve (AUC)) with duration of exposure to heat (indicated on the right axis). The left axis corresponds to the AUC for the parabens, which demonstrates a corresponding decrease. b The percent of paraben degradation product relative to total parabens as a function of time. Degraded parabens byproduct increases in abundance with increasing exposure to heat