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Table 2 Odds of invasive bacterial infection in ALIVE participants with cessation and reduced intensity injection

From: Reducing injection intensity is associated with decreased risk for invasive bacterial infection among high-frequency injection drug users

Variables 3-month observationa 6-month observationa
Unadjusted Adjustedb Unadjusted Adjustedb
OR (95% CI) p OR (95% CI) p OR (95% CI) p OR (95% CI) p
Age (per 10 year) 1.18 (0.95–1.46) 0.135 1.30 (1.03–1.66) 0.029 1.21 (1.04–1.42) 0.012 1.34 (1.13–1.59) 0.001
Gender (female) 1.26 (0.86–1.84) 0.229 1.74 (1.17–2.57) 0.043 1.50 (1.14–1.97) 0.003 1.76 (1.34–2.32) < 0.001
HIV status by CD4 count
 HIV negative > 500 cells/mm3 1.0 (Ref)
3.13 (1.72–5.70)
<0.001 1.0 (Ref)
3.71 (2.03–6.79)
< 0.001 1.0 (Ref)
3.01 (1.97-4.59)
< 0.001 1.0 (Ref)
3.52 (2.3–5.39)
< 0.001
 200–499 cells/mm3 5.13 (3.21–8.19) < 0.001 5.81 (3.63–9.29) < 0.001 4.96 (3.57–6.88) < 0.001 5.52 (3.97–7.69) < 0.001
 < 200 cells/mm3 11.06 (6.98–17.55) < 0.001 11.55 (7.23–18.43) < 0.001 10.31 (7.41–14.3) < 0.001 10.39 (7.44–14.5) < 0.001
Injection intensity
 High intensity 1.0 (Ref)   1.0 (Ref)   1.0 (Ref)   1.0 (Ref)  
 Reduced intensity 0.74 (0.50–1.09) 0.126 0.64 (0.43–0.96) 0.031 0.81 (0.62–1.06) 0.121 0.74 (0.56–0.98) 0.035
 Cessation of injection 0.62 (0.36–1.07) 0.084 0.46 (0.25–0.84) 0.012 0.65 (0.45–0.95) 0.025 0.54 (0.36–0.81) 0.003
  1. CI confidence interval, Ref reference
  2. aData are odds ratios (95% confidence intervals)
  3. bEach model adjusted for race, non-injection drug use, alcohol use, and tobacco use