Table 1 Nicotine pharmacokinetic parameters for BIDI stick® ENDS and comparator products
UB cigarette | BIDI® Stick Arctic | BIDI® Stick Classic | BIDI® Stick Regal | BIDI® Stick Solar | BIDI® Stick Winter | BIDI® Stick Zest | JUUL VT | |
|---|---|---|---|---|---|---|---|---|
Cmax 0–120 (ng/mL) | ||||||||
Mean [SD] | 16.2 [9.17] | 16.8 [9.71] | 17.6 [9.00] | 15.6 [8.72] | 16.0 [11.73] | 15.3 [9.90] | 17.2 [10.30] | 6.8 [4.13] |
Geometric mean [SD] | 14.0 [1.74] | 13.5 [2.18] | 15.5 [1.68] | 13.4 [1.80] | 12.6 [2.07] | 13.1 [1.76] | 14.7 [1.77] | 5.7 [1.89] |
Median | 13.9 | 16.6 | 13.3 | 13.7 | 11.1 | 12.0 | 11.6 | 5.7 |
Min, max | 4.7, 40.6 | 1.4, 36.8 | 7.1, 33.9 | 3.8, 37.0 | 2.6, 41.2 | 4.4–44.6 | 5.4–42.7 | 1.8–14.8 |
AUC0-120 (min*ng/mL) | ||||||||
Mean [SD] | 747.1 [325.48] | 592.0 [254.76] | 616.9 [296.45] | 572.4 [315.83] | 628.6 [408.99] | 569.7 [327.29] | 620.3 [283.86] | 243.6 [179.04] |
Geometric mean [SD] | 679.1 [1.59] | 464.2 [2.94] | 560.2 [1.57] | 489.5 [1.84] | 511.7 [2.07] | 480.4 [1.89] | 558.8 [1.65] | 161.4 [3.06] |
Median | 665.5 | 602.4 | 607.2 | 582.3 | 532.9 | 462.6 | 558.3 | 245.4 |
Min, max | 233.4, 1448.4 | 8.64, 1118.8 | 248.1, 1491.0 | 137.1, 1412.1 | 61.6, 1679.2 | 111.7, 1206.6 | 136.8, 1312.7 | 8.9, 588.2 |
Tmax 0–120 (min) | ||||||||
Mean [SD] | 6.7 [2.74] | 6.2 [1.39] | 6.1 [1.41] | 6.0 [1.58] | 6.1 [1.58] | 6.0 [1.41] | 6.8 [2.51] | 5.9 [1.73] |
Median | 6 | 7 | 5 | 5 | 7 | 5 | 7 | 5 |
Min, max | 3, 15 | 5, 10 | 5, 10 | 3, 10 | 3, 10 | 5, 10 | 5, 15 | 3, 10 |
Cmax 120–180 (ng/ml) | ||||||||
Mean [SD] | 11.0 [5.30] | 23.7 [12.67] | 19.6 [10.43] | 15.9 [13.29] | 20.0 [11.73] | 19.6 [14.67] | 19.4 [10.21] | 11.3 [10.85] |
Geometric mean [SD] | 10.04 [1.53] | 18.61 [2.09] | 17.32 [1.67] | 12.44 [2.54] | 16.96 [1.82] | 16.86 [2.03] | 17.56 [1.78] | 8.52 [2.37] |
Median | 9.3 | 28.8 | 18.4 | 11.4 | 20.1 | 15.0 | 16.3 | 6.8 |
Min, max | 4.9, 25.6 | 3.5, 38.4 | 8.5, 42.7 | 0.9, 48.9 | 7.4, 44.2 | 4.9, 50.1 | 5.3, 40.6 | 1.7, 41.2 |