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Table 2 Statistical comparison of nicotine pharmacokinetic parameters

From: A randomised, crossover, clinical study to assess nicotine pharmacokinetics and subjective effects of the BIDI® stick ENDS compared with combustible cigarettes and a comparator ENDS in adult smokers

 

BIDI® Stick Arctic

BIDI® Stick Classic

BIDI® Stick Regal

BIDI® Stick Solar

BIDI® Stick Winter

BIDI® Stick Zest

JUUL VT

Cmax 0–120 LS Means [90% CI]a

 BIDI Stick® Classic ENDS

0.89 [0.71,1.12]

 BIDI Stick® Regal ENDS

1.01 [0.80,1.27]

1.13 [0.90,1.43]

 BIDI Stick® Solar ENDS

1.07 [0.85,1.35]

1.20 [0.95,1.51]

1.06 [0.84,1.33]

 BIDI Stick® Winter ENDS

1.05 [0.83,1.33]

1.18 [0.93,1.49]

1.04 [0.82,1.31]

0.98 [0.78,1.24]

 BIDI Stick® Zest ENDS

0.94 [0.75,1.19]

1.06 [0.84,1.33]

0.93 [0.74,1.18]

0.88 [0.70,1.11]

0.89 [0.71,1.13]

 JUUL VT ENDS

2.44 [1.93,3.08]

2.74 [2.17,3.45]

2.42 [1.91,3.05]

2.28 [1.81,2.88]

2.32 [1.84,2.93]

2.59 [2.06,3.27]

 UB cigarette

1.00 [0.72,1.38]

1.12 [0.81,1.55]

0.99 [0.71,1.37]

0.93 [0.67,1.29]

0.95 [0.68,1.32]

1.06 [0.77,1.47]

0.41 [0.30,0.57]

AUC0-120 LS Means [90% CI]a

 BIDI Stick® Classic ENDS

0.83 [0.63,1.09]

 BIDI Stick® Regal ENDS

0.97 [0.73,1.28]

1.17 [0.88,1.55]

 BIDI Stick® Solar ENDS

0.94 [0.71,1.24]

1.13 [0.85,1.5]

0.97 [0.73,1.28]

 BIDI Stick® Winter ENDS

0.99 [0.75,1.31]

1.20 [0.91,1.59]

1.02 [0.77,1.36]

1.06 [0.8,1.41]

 BIDI Stick® Zest ENDS

0.84 [0.63,1.11]

1.01 [0.76,1.34]

0.86 [0.65,1.14]

0.89 [0.67,1.18]

0.84 [0.64,1.11]

 JUUL VT ENDS

2.93 [2.21,3.88]

3.54 [2.68,4.69]

3.03 [2.29,4.01]

3.13 [2.37,4.15]

2.95 [2.23,3.91]

3.51 [2.65,4.64]

 UB cigarette

0.70 [0.47,1.04]

0.84 [0.57,1.25]

0.72 [0.49,1.07]

0.75 [0.5,1.11]

0.70 [0.48,1.04]

0.84 [0.56,1.24]

0.24 [0.16,0.35]

Tmax 0–120 Odds Ratios [90% CI]b

 BIDI Stick® Classic ENDS

0.79 [0.25,2.42]

 BIDI Stick® Regal ENDS

0.70 [0.23,2.16]

0.89 [0.29,2.76]

 BIDI Stick® Solar ENDS

0.84 [0.27,2.58]

1.07 [0.35,3.30]

1.20 [0.39,3.71]

 BIDI Stick® Winter ENDS

0.65 [0.21,2.02]

0.83 [0.27,2.58]

0.93 [0.30,2.90]

0.78 [0.25,2.41]

 BIDI Stick® Zest ENDS

1.40 [0.46,4.29]

1.79 [0.58,5.49]

2.01 [0.65,6.19]

1.67 [0.54,5.13]

2.15 [0.70,6.65]

 JUUL VT ENDS

0.59 [0.19,1.82]

0.75 [0.24,2.33]

0.84 [0.27,2.62]

0.70 [0.23,2.18]

0.90 [0.29,2.81]

0.42 [0.13,1.30]

 UB cigarette

1.08 [0.36,3.27]

1.38 [0.45,4.19]

1.54 [0.51,4.71]

1.29 [0.42,3.91]

1.66 [0.54,5.06]

0.77 [0.26,2.32]

1.84 [0.60,5.65]

  1. Statistical significance is concluded if the CIs do not contain 1.00
  2. UB usual brand; LS least square; CI confidence interval; and VT Virginia Tobacco. Values which were significantly different are in bold type
  3. N = 17–18 in each case
  4. aBack-transformed (exponentiated) linear mixed model parameter estimates used to create 90% CI ratios of geometric least-squares means between study products
  5. bOdds ratios 90% CIs