Adherence to opioid agonist therapy predicts uptake of direct-acting antivirals in people who use drugs: results from the French national healthcare database (the ANRS FANTASIO study)

Table 2 Characteristics of PWUD with chronic hepatitis C and factors associated with adherence to OAT in the previous six months, univariable and multivariable mixed effects linear regression models (ANRS FANTASIO study; 22,615 patients)

Variables	Univariable analyses		Multivariable analysis
Variables	Coef [95% CI]	p-value	aCoef [95% CI]	p-value
Sex
Male (ref.)	0		0
Female	1.45 [0.67; 2.23]	< 0.001	1.35 [0.57; 2.13]	0.001
Age (per 1-year increase)	− 0.09 [− 0.13; − 0.05]	< 0.001	− 0.09 [− 0.13; − 0.04]	< 0.001
Receiving CMU-C
No (ref.)	0		0
Yes	0.75 [0.05; 1.44]	0.035	0.52 [− 0.18; 1.22]	0.147
Liver disease severity
No cirrhosis and no liver cancer (ref.)	0		0
Cirrhosis without liver cancer	1.23 [− 0.55; 3.00]	0.176	1.79 [− 0.01; 3.59]	0.051
Liver cancer	0.39 [− 2.69; 3.47]	0.804	1.32 [− 1.79; 4.42]	0.406
Alcohol use disorder (AUD)
No (ref.)	0		0
Yes	− 0.58 [− 1.34; 0.18]	0.132	− 0.77 [− 1.53; 0.01]	0.051

aCoef, Adjusted regression coefficient; CI, confidence interval; CMU-C, complementary universal health coverage status (Couverture Maladie Universelle – complémentaire); Coef, regression coefficient; OAT, opioid agonist therapy; PWUD, people who use drugs

ISSN: 1477-7517