Fig. 3
From: A method of diamorphine (heroin) administration for harm reduction
A A typical heroin infusion will generate supersaturation as the heroin concentration (C*) is higher than the heroin solubility (Ceq) at blood pH 7.4. The pH shift and precipitation processes are indicated by the arrows. B The rate of infusion on the generated supersaturation ratio, slower rates provide more time for a greater blood volume, effectively diluting the solution and reducing the supersaturation ratio. Larger supersaturation ratios will result in a more rapid rate of precipitation. C Increasing infusion time can significantly reduce the βindex, as illustrated using ascorbic acid data