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The impact of exposure to physical and sexual violence on opioid consequences among trauma-exposed individuals recruited from the community who use opioids

Harm Reduction Journal volume 20, Article number: 167 (2023) Cite this article

Abstract

Interpersonal violence and opioid use disorder are significant and intersecting public health concerns in the USA. The current study evaluated the consequences associated with opioid use (e.g., physical, social, interpersonal, intrapersonal, and impulse control) as a function of a history of exposure to interpersonal trauma, specifically physical and sexual violence. Participants were 84 trauma-exposed individuals recruited from the community who use opioids (M age = 43.5 50% men; 55% white). Whereas no significant differences emerged in the consequences of opioid use based on a history of physical violence, individuals with a history of sexual violence demonstrated higher levels of impulsive consequences of opioid use compared to individuals without a history of sexual violence. These data highlight the importance of considering the role of exposure to sexual violence in the context of opioid use disorder treatment.

Opioid use disorder is a growing public health concern in the USA with high prevalence, morbidity, and mortality [1,2,3]. The Centers for Disease Control (CDC) estimated there have been more than 500,000 opioid overdose deaths in the USA over the past two decades [4]. Nationally, fatal opioid overdoses reached an all-time high in the USA in 2022, with more than 80,000 opioid-related overdose death reported [5]. Whereas opioid use is emerging as an epidemic, interpersonal trauma, which includes sexual and physical violence, has been documented as long as people have been recording history [6]. Sexual violence encompasses forcing or attempting to force a person to engage in sexual activity or touching and physical violence involves hurting, attempting to hurt, or threatening to hurt another person by use of physical force or weapons [7]. In the USA, both physical and sexual violence is highly prevalent. For example, a review of 249 articles revealed that in their lifetimes, 23.1% of women and 19.3% of men experienced physical violence [8]. The 2015 National Intimate Partner and Sexual Violence Survey (NISVS) revealed that 19.3% of women (out of 5,758) and 1.7% of men (out of 4,323) have been raped and 43.9% of women and 23.4% of men experienced other forms of sexual violence such as unwanted sexual contact [7].

These two public health concerns, namely opioid use and interpersonal trauma, are interrelated and bidirectional in nature. Prior research has highlighted the role of interpersonal trauma in contributing to problematic opioid use outcomes, including opioid use disorder and opioid overdose [9,10,11]. This can be explained by the opioid susceptibility model or self-medication model which posits that individuals with a history of interpersonal trauma may use opioids to cope with trauma-related psychological distress [e.g., posttraumatic stress disorder (PTSD)], physical pain and injuries, and psychosomatic symptoms (e.g., headaches, backpains), which increases their risk for developing opioid use disorder [12,13,14,15,16,17]. Opioid use also increases the risk of exposure to interpersonal trauma [18,19,20,21,22,23]. Contextual factors such as the decreased ability to assess risk when impaired by drugs, dependence on sexual partners for drug supply, coercion from an abusive partner to use drugs, and being forced to have sex in exchange for drugs or money, have all shown an increased risk for exposure to interpersonal trauma [20, 24,25,26,27]. Notably, the co-occurrence of opioid use and interpersonal trauma is marked by worsened clinical consequences associated with opioid use (e.g., exacerbations of psychological distress, increased opioid use), increased social consequences (e.g., legal, financial, and/or family problems), and poorer opioid use disorder treatment outcomes (e.g., higher rates of treatment drop out, more missed treatment appointments) [28,29,30,31,32,33,34,35].

Whereas extant research provides robust evidence for the relationship between opioid use and exposure to interpersonal trauma, there is an important gap. Namely, prior studies tended to limit their investigation to a single type of interpersonal trauma [e.g., only sexual violence [12, 20, 35, 36]]. When studies have examined multiple types of interpersonal trauma, they combined different types of interpersonal violence (such as sexual violence and physical violence) in a single composite variable [37,38,39]. This limits insight into whether different types of interpersonal trauma are differently related to consequences associated with opioid use. Nascent research has begun investigating the role of different types of trauma in the development and maintenance of opioid use disorder. For example, one study examined the impact of different types of interpersonal violence (i.e., intimate partner violence, sexual assault, and adverse childhood experiences) on problematic opioid use and found that only intimate partner violence and adverse childhood experiences were related to problematic opioid use [40]. Whereas this study examined different trauma types, they did not distinguish between physical and sexual violence. Two studies examined the pathways from childhood abuse to lifetime problematic opioid use among women and found that only sexual abuse—but not physical abuse, emotional abuse, or neglect—was associated with problematic opioid use [41, 42]. However, these are two studies, and thus there is a need for further investigation into the potentially differential impact of distinct types of interpersonal trauma.

Present study

The current study investigated consequences associated with opioid use (i.e., physical, social, interpersonal, intrapersonal, and impulse control) based on participant’s history of exposure to interpersonal trauma, specifically physical and sexual violence. Consistent with the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) [43] exposure to interpersonal trauma was defined as direct experiences, witnessing (in person) the event, learning the event happened to a close family member or friend, or experiencing repeated or extreme exposure to aversive details of the event(s) (e.g., first responders). Given that opioid use and interpersonal trauma co-occur at high rates [10, 12] leads to worse outcomes [28, 29, 32, 35], and different types of trauma may be more relevant [41, 42] it was hypothesized as follows:

Hypothesis 1

Individuals with a history of exposure to physical violence would report significantly more consequences of opioid use, compared to those without a history of exposure to physical violence.

Hypothesis 2

Individuals with a history of exposure to sexual violence would report significantly more consequences of opioid use, compared to those without a history of exposure to sexual violence.

Methods

Participants

Participants were recruited from the Providence metropolitan area, an urban region anchored by the city of Providence, Rhode Island with a population of greater than 1.6 million. Recruitment materials were posted in community establishments throughout Providence County, Rhode Island including grocery stores, laundromats, and shops; selected state offices such as the Office of Housing and Community Development; and waiting rooms, bathrooms, and examination rooms of urban-area primary care clinics; as well as in website postings (e.g., Craigslist). Further, research assistants recruited at/alongside local harm reduction agencies (e.g., street outreach, warming centers) that serve individuals who use opioids (e.g., needle exchange). Eligibility was determined through self-report during a phone or in-person screen. Participants were individuals who had experienced trauma in their lifetime and used illegal opioids (e.g., heroin) or misused prescription opioids (i.e., used prescription opioids without a prescription or in a manner not prescribed such as taking a higher dose than prescribed or for a longer period than prescribed) during the past 30 days. Specifically, Item 1 of the Primary Care PTSD Screen for DSM-5 [44] was used to assess past 30-day trauma exposure. Specifically, participants were asked: “Sometimes things happen to people that are unusually or especially frightening, horrible, or traumatic. For example, a serious accident or fire, a physical or sexual assault or abuse, an earthquake or flood, a war, seeing someone be killed or seriously injured, having a loved one die through homicide or suicide. Have you ever experienced this kind of event?” Further, three items were administered to assess past 30-day opioid use. Specifically, participants were asked: “In the last month, did you use (1) opioids, (2) prescription pain relievers such as oxycodone, hydrocodone, codeine, or morphine that were not prescribed to you or use prescription drugs not as prescribed in order to feel the effects? (e.g., you took more than prescribed or took them for a longer time than prescribed); or (3) synthetic opioids like fentanyl that were not prescribed to you or use prescription drugs not as prescribed in order to feel the effects? (e.g., you took more than prescribed or took them for a longer time than prescribed).” If they answered yes to opioid items 1, 2, or 3, they were eligible for the study. One-hundred and sixty individuals called to learn more about the study, two of whom were not interested with proceeding with screening questions after learning what the study entailed. Of the people who were screened (n = 158), 41 were not eligible. Of the eligible participants (n = 117), two were not interested in being scheduled after they were screened. Thus, 115 participants were eligible and scheduled. Of the participants who were scheduled, 31 participants dropped out prior to consent (baseline session), leaving 84 participants in the final sample.

Additional inclusion criteria were: (1) age 18 or older, (2) fluent in the English language, and (3) owning a smartphone. Exclusion criteria were (a) current mania/psychosis (assessed in the baseline session with the Structured Clinical Interview for DSM-V [SCID-5]; First and Williams, 2016) and (b) current impairment in cognitive functioning (assessed in the baseline session using the mini-mental status examination and requiring a score > 24; Folstein et al., 1975). The sample reported here included 84 individuals who participated in a baseline session; demographic characteristics are summarized in Table 1.

Table 1 Demographic summary
Full size table

Procedures

All procedures were reviewed and approved by the [redacted] Institutional Review Board. The larger study entailed (a) a baseline session, (b) 30 days of ecological momentary assessment (five surveys per day) on a smartphone app, and (c) a follow-up session. The current study used data from the baseline session. Baseline sessions were conducted by a clinical psychology doctoral student in a private office to protect participants’ safety and confidentiality. After providing informed consent, participants were interviewed using a structured diagnostic assessment and then answered self-report measures on a computer. Participants were compensated with $25 for completing the baseline session. Participants were provided with a list of community resources. Assistance with referrals was provided upon participant request. The principal investigator (author [redacted]), a licensed psychologist in the state of Rhode Island, was available on-call if participants required additional trauma- and/or substance-related support.

Measures

Interpersonal trauma

The 17-item Life Events Checklist for DSM-5 [LEC-5; [45]] was used to assess a history of exposure to physical violence or sexual violence. Participants rated each time with six response options: happened to me, witnessed it, learned about it, part of my job, not sure, or doesn’t apply. Specifically, items “Assault with a weapon (for example, being shot, stabbed, threatened with a knife, gun, bomb)” and “Physical assault (for example, being attacked, hit, slapped, kicked, beaten up)” were used to measure the experience of exposure to physical violence, whereas “Sexual assault (rape, attempted rape, made to perform any type of sexual act through force or threat of harm)” and “Other unwanted or uncomfortable sexual experience” were used to measure the experience of exposure to sexual violence. For the current study, exposure to physical or sexual violence was indicated when participants selected either “happened to me,” “witnessed it,” “learned about it,” or “part of my job,” as consistent with Criterion A for posttraumatic stress disorder in the Diagnostic Statistical Manual of Mental Disorder, Edition 5 [DSM-5 [46]].

Consequences associated with opioid use

The 17-item Short Inventory of Problems Scale-Revised [SIPR; [47]] was adapted to assess consequences associated with opioid use. The scale has five subscales: physical consequences (“Because of my opioid use, I have lost weight or not eaten properly”), social consequences ("I have failed to do what is expected of me because of my opioid use”), intrapersonal consequences ("I have felt guilt or ashamed because of my opioid use”), impulse control (“I have taken foolish risks when I have been using opioids”), and interpersonal consequences (“My family has been hurt by my opioid use”). Participants responded on a 4-point Likert scale, ranging from 0 (Never) to 3 (Daily or Almost Daily). Items were summed and higher scores indicated more frequently experienced problems associated with opioid use. The internal consistency of all five subscales ranged from good to excellent. McDonald’s Omega was as follows: 0.84 (physical consequences), 0.93 (social consequences), 0.89 (intrapersonal consequences), 0.89 (interpersonal consequences), and 0.93 (impulsive consequences).

Data analysis

Descriptive data for the primary study variables were calculated. In order to examine whether consequences of opioid use varied across history of exposure to physical violence, one-way ANOVA was conducted where a history of exposure to physical violence (0 = no history of exposure to physical violence, 1 = history of exposure to physical violence) was entered as the independent variable, and consequences of opioid use (i.e., physical, social, intrapersonal, interpersonal, and impulsive) were entered as dependent variables. Similarly, to examine whether consequences of opioid use varied across a history of exposure to sexual violence, one-way ANOVA was conducted where a history of exposure to sexual violence (0 = no history of exposure to sexual violence, 1 = history of exposure to sexual violence) was entered as the independent variable and consequences of opioid use (i.e., physical, social, intrapersonal, interpersonal, and impulsive) were entered as dependent variables.

Results

Preliminary analyses

When examining past-month opioid use in the current sample, 59.5% (n = 50) reported using heroin, 70.2% (n = 59) reported using prescription opioids without a prescription or in a manner not prescribed such as taking a higher dose than prescribed or for a longer period than prescribed, and 82.1% (n = 69) reported using synthetic opioids (e.g., Fentanyl). All participants in the current study reported a history of trauma. When examining exposure to interpersonal violence in the current sample, over half of the sample reported a history of exposure to physical (n = 56; 66.7%) or sexual (n = 47; 56.0%) violence. Over half of the sample, (n = 45, 53.57%) endorsed exposure to both physical and sexual violence. Further details regarding the prevalence of history of exposure to physical and sexual violence are summarized in Table 2.

Table 2 Prevalence of interpersonal trauma
Full size table

Impact of exposure to physical and sexual violence

See Table 3 for one-way ANOVA tests examining consequences of opioid use as a function of history of exposure to physical and sexual violence. No significant differences emerged in the physical, social, intrapersonal, interpersonal, or impulsive consequences of opioid use based on a history of exposure to physical violence. Conversely, individuals with a history of exposure to sexual violence demonstrated significantly higher levels of impulsive (M = 5.34, SD = 3.44)—but not physical, social, intrapersonal, or interpersonal—consequences compared to individuals without a history of exposure to sexual violence (M = 3.53, SD = 3.06).

Table 3 Differences in consequences of opioid use by history of exposure to physical and sexual violence
Full size table

Discussion

The current study investigated the unique impact of exposure to physical and sexual violence on consequences associated with opioid use among trauma-exposed individuals recruited from the community who use opioids. The link between exposure to interpersonal trauma and increased consequences associated with opioid use has been well established in prior literature [28, 29, 32, 35]. To our knowledge, this is the first study to examine whether the consequences of opioid use differed based on participant’s history of exposure to interpersonal trauma, specifically physical and sexual violence.

Contrary to our hypothesis, individuals with a history of exposure to physical violence reported similar levels of consequences associated with opioid use, compared to individuals without a history of exposure to physical violence. Our second hypothesis, specifically, individuals with a history of exposure to sexual violence would report higher levels of consequences associated with opioid use, compared to individuals without a history of exposure to sexual violence, was partially supported. Specifically, results suggested that individuals with a history of exposure to sexual violence demonstrated significantly high levels of impulsive consequences—but not physical, social, intrapersonal, or interpersonal consequences—of opioid use compared to individuals without a history of exposure to sexual violence. Results are in line with prior studies that indicate sexual violence, compared to other types of violence, is particularly detrimental, even when compared to physical violence [48, 49]. It warrants mention that the current sample consisted of all trauma-exposed individuals. This history of exposure to trauma may explain why most of the consequences of opioid use, except for impulsive consequences, did not differ among individuals who did and did not experience exposure to physical or sexual violence. Future research is needed to compare individuals with physical and sexual violence to those without any history of trauma on their consequences of opioid use.

Notably, results highlight the particularly adverse impact of exposure to sexual violence on impulsive consequences of opioid use. The link between a history of exposure to sexual violence and consequences associated with opioid use, especially impulsive consequences, may be understood through the lens of emotion dysregulation. Emotion dysregulation is a multifaceted construct that refers to difficulties understanding and modulating emotions [50]. Robust evidence shows that individuals with a history of exposure to sexual violence demonstrate higher levels of emotion dysregulation compared to those without a history of exposure to sexual violence [51,52,53]. Emotion dysregulation, in turn, is also associated with impulsive behaviors [54,55,56], including among individuals with a history of exposure to sexual violence [52, 57, 58]. Further, deficits in emotion regulation among individuals with a history of exposure to sexual violence have also been linked to greater problematic substance use [for a review, see [59]], including opioid use [12, 60], which is consistent with the self-medication/opioid susceptibility hypothesis [17, 61]. Collectively, findings suggest the utility of targeting emotion dysregulation to address impulsivity consequences of opioid use among individuals with a history of exposure to sexual violence [for a review see [62]].

Another possible reason that may explain the findings of current study is the link between PTSD and impulsivity. Individuals exposed to sexual violence are at an exponentially greater risk for developing PTSD, compared to other types of trauma (e.g., physical assault) [63,64,65]. Further, robust evidence has linked PTSD symptoms to heightened impulsivity [66, 67], and heightened impulsivity with increased substance use [68, 69]. Although not assessed here, individuals exposed to sexual violence in the current study may be at an increased risk for using opioids due to increased PTSD symptoms and the impact of PTSD on impulsivity. Subsequently, opioid use may then exacerbate impulse control consequences. Indeed, one study compared levels of impulsivity among individuals with concurrent OUD and PTSD, OUD without PTSD, PTSD without OUD, and individuals without OUD or PTSD [70]. The authors found that the concurrent OUD and PTSD, OUD without PTSD, and PTSD without OUD groups reported higher levels of impulsivity compared to individuals without OUD or PTSD. Additionally, the authors also found that the concurrent OUD and PTSD group also reported greater levels of impulsivity compared to the OUD without PTSD group and individuals without OUD or PTSD but not the PTSD without OUD group. Thus, the authors’ concluded that impulsivity mechanism links OUD and PTSD which may explain why individuals exposed to sexual violence in the current study, who are at a greater risk for experiencing PTSD, may also show greater levels of impulse control consequences related to opioid use.

Study results have several implications for clinical practice and research. Given the detrimental impact of comorbid sexual violence and problematic opioid use, clinicians should incorporate regular screening for exposure to sexual violence in treatment for opioid use disorder. Given that many individuals exposed to sexual violence may delay disclosure of violence to treatment providers [71], and problematic opioid use is associated with increased risk for exposure to sexual violence [20], it is important for clinicians to routinely screen for exposure to sexual violence. Further efforts need to be targeted toward the development and evaluation of interventions aimed at concomitantly reducing exposure to sexual violence and problematic opioid use to effect a change in harmful effects of both exposure to sexual violence and opioid use. Such efforts can be built on prior work that has already been done on alcohol and its relationship to exposure to sexual violence while heeding to unique differences that may exist between alcohol-involved exposure to sexual violence and opioid-involved exposure to sexual violence [72]. Given the bidirectional nature of exposure to sexual violence and problematic opioid use, interventions targeting opioid use among individuals exposed to sexual violence also need to be developed and evaluated [36]. Finally, the results highlight the need to incorporate a trauma-informed approach in care and treatment for opioid use disorder such as fostering collaboration, maximizing client’s choice and control, emphasizing client’s strengths, and creating a safe atmosphere [73].

Limitations and future directions

The results of the current study should be interpreted in the context of several limitations, which also pave the way for future directions. First, our relatively small sample size limits investigation into gender differences, polyvictimization (i.e., experiencing more than one type of interpersonal violence), and revictimization (i.e., repeated occurrences of interpersonal violence). Preliminary research suggests gender differences in the relation between interpersonal violence and opioid use [40, 42], and both polyvictimization and revictimization are associated with increased substance use [74, 75]. Thus, future studies with larger sample size should determine the role of gender, polyvictimization, and revictimization in the relations between both exposure to physical and sexual violence and problematic opioid use. Second, given that cross-sectional findings preclude temporal interpretations, future longitudinal studies with multiple time points are needed to establish the likely cyclical relation between exposure to sexual violence and problematic opioid use. Finally, findings cannot be assumed to generalize to other populations characterized by opioid use, including individuals seeking outpatient or residential treatment for problematic opioid use. Thus, findings require replication across other populations that use opioids.

Conclusion

The current study investigated differences in consequences associated with opioid use depending on history of exposure to interpersonal trauma, particularly physical and sexual violence, among trauma-exposed individuals recruited from the community who use opioids. Results suggest that individuals with a history of exposure to sexual violence in particular demonstrated a higher level of impulsive consequences associated with opioid use. Findings emphasize the need to concomitantly address both sexual violence and problematic opioid use.

Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request.

Abbreviations

CDC:

Centers for disease control

PTSD:

Posttraumatic stress disorder

SCID-5:

Structured clinical interview for DSM-V

DSM-5:

Diagnostic statistical manual of mental disorder, edition 5

LEC-5:

Life events checklist for DSM-5

SIPR:

Short inventory of problems scale-revised

References

  1. Hedden SL. Behavioral health trends in the United States: results from the 2014 National Survey on Drug Use and Health: Substance Abuse and Mental Health Services Administration, Department of … 2015

  2. Hall W, Degenhardt L, Hickman M. Generational trends in US opioid-overdose deaths. Nat Med. 2020;26(5):651–2.

    Article  CAS  PubMed  Google Scholar 

  3. Multiple Cause of Death 1999–2020 on CDC WONDER Online Database. Centers for Disease Control and Prevention, National Center for Health Statistics; 2021

  4. Understanding the Epidemic 2021

  5. Ahmad F, Cisewski J, Rossen LM, Sutton P. Provisional drug overdose death counts. National Center for Health Statistics; 2023.

  6. Arafat KW, Arieti JA, Byrne L, Harrison T, Hopwood K, Kilmer M, et al. Rape in Antiquity Sexual Violence in the Greek and Roman Worlds. In: Deacy S, Pierce KF, editors., et al., Rape in Antiquity. Classical Press of Wales; 2002.

    Google Scholar 

  7. Breiding M, Basile KC, Smith SG, Black MC, Mahendra RR. Intimate partner violence surveillance: Uniform definitions and recommended data elements. Version 2.0. 2015

  8. Desmarais SL, Reeves KA, Nicholls TL, Telford RP, Fiebert MS. Prevalence of physical violence in intimate relationships part 1: rates of male and female victimization. Partn Abus. 2012;3(2):140–69.

    Article  Google Scholar 

  9. Stein MD, Conti MT, Kenney S, Anderson BJ, Flori JN, Risi MM, et al. Adverse childhood experience effects on opioid use initiation, injection drug use, and overdose among persons with opioid use disorder. Drug Alcohol Depend. 2017;179:325–9.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Quinn K, Boone L, Scheidell JD, Mateu-Gelabert P, McGorray SP, Beharie N, et al. The relationships of childhood trauma and adulthood prescription pain reliever misuse and injection drug use. Drug Alcohol Depend. 2016;169:190–8.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Austin AE, Shanahan ME. Association of childhood abuse and neglect with prescription opioid misuse: examination of mediation by adolescent depressive symptoms and pain. Child Youth Serv Rev. 2018;86:84–93.

    Article  Google Scholar 

  12. Austin AE, Short NA. Sexual violence, mental health, and prescription opioid use and misuse. Am J Prev Med. 2020;59(6):818–27.

    Article  PubMed  Google Scholar 

  13. Sturza ML, Campbell R. An exploratory study of rape survivors’ prescription drug use as a means of coping with sexual assault. Psychol Women Q. 2005;29(4):353–63.

    Article  Google Scholar 

  14. Stone R, Rothman EF. Opioid use and intimate partner violence: a systematic review. Current Epidemiology Reports. 2019;6(2):215–30.

    Article  Google Scholar 

  15. Campbell JC. Health consequences of intimate partner violence. The Lancet. 2002;359(9314):1331–6.

    Article  Google Scholar 

  16. Campbell J, Jones AS, Dienemann J, Kub J, Schollenberger J, O’Campo P, et al. Intimate partner violence and physical health consequences. Arch Intern Med. 2002;162(10):1157–63.

    Article  PubMed  Google Scholar 

  17. Danovitch I. Post-traumatic stress disorder and opioid use disorder: a narrative review of conceptual models. J Addict Dis. 2016;35(3):169–79.

    Article  PubMed  Google Scholar 

  18. Argento E, Chettiar J, Nguyen P, Montaner J, Shannon K. Prevalence and correlates of nonmedical prescription opioid use among a cohort of sex workers in Vancouver. Canada Int J Drug Policy. 2015;26(1):59–66.

    Article  PubMed  Google Scholar 

  19. Argento E, Muldoon KA, Duff P, Simo A, Deering KN, Shannon K. High prevalence and partner correlates of physical and sexual violence by intimate partners among street and off-street sex workers. PLoS ONE. 2014;9(7): e102129.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Jessell L, Mateu-Gelabert P, Guarino H, Vakharia SP, Syckes C, Goodbody E, et al. Sexual violence in the context of drug use among young adult opioid users in New York City. J Interpers Violence. 2017;32(19):2929–54.

    Article  PubMed  Google Scholar 

  21. Mateu-Gelabert P, Guarino H, Jessell L, Teper A. Injection and sexual HIV/HCV risk behaviors associated with nonmedical use of prescription opioids among young adults in New York City. J Subst Abuse Treat. 2015;48(1):13–20.

    Article  PubMed  Google Scholar 

  22. Fowler DN, Faulkner M. Interventions targeting substance abuse among women survivors of intimate partner abuse: a meta-analysis. J Subst Abuse Treat. 2011;41(4):386–98.

    Article  PubMed  Google Scholar 

  23. Hall MT, Golder S, Higgins GE, Logan TK. Nonmedical prescription opioid use among victimized women on probation and parole. Addict Behav. 2016;53:113–9.

    Article  PubMed  Google Scholar 

  24. El-Bassel N, Gilbert L, Witte S, Wu E, Chang M. Intimate partner violence and HIV among drug-involved women: contexts linking these two epidemics—challenges and implications for prevention and treatment. Subst Use Misuse. 2011;46(2–3):295–306.

    Article  PubMed  Google Scholar 

  25. Littleton H, Grills-Taquechel A, Axsom D. Impaired and incapacitated rape victims: assault characteristics and post-assault experiences. Violence Vict. 2009;24(4):439–57.

    Article  PubMed  Google Scholar 

  26. Warshaw C, Lyon E, Bland PJ, Phillips H, Hooper M. Mental health and substance use coercion surveys. Report from the National Center on Domestic Violence, Trauma & Mental Health and the National Domestic Violence Hotline: National Center on Domestic Violence, Trauma & Mental Health and the National Domestic Violence Hotline. 2014

  27. Birnbaum HG, White AG, Schiller M, Waldman T, Cleveland JM, Roland CL. Societal costs of prescription opioid abuse, dependence, and misuse in the United States. Pain Med. 2011;12:657–67.

    Article  PubMed  Google Scholar 

  28. Blanco C, Xu Y, Brady K, Pérez-Fuentes G, Okuda M, Wang S. Comorbidity of posttraumatic stress disorder with alcohol dependence among US adults: results from national epidemiological survey on alcohol and related conditions. Drug Alcohol Depend. 2013;132(3):630–8.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Katzman MA, Bleau P, Blier P, Chokka P, Kjernisted K, Van Ameringen M. Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders. BMC Psychiatry. 2014;14(1):1–83.

    Article  Google Scholar 

  30. Peirce JM, Brooner RK, King VL, Kidorf MS. Effect of traumatic event reexposure and PTSD on substance use disorder treatment response. Drug Alcohol Depend. 2016;158:126–31.

    Article  PubMed  Google Scholar 

  31. Hien DA, Nunes E, Levin FR, Fraser D. Posttraumatic stress disorder and short-term outcome in early methadone treatment. J Subst Abuse Treat. 2000;19(1):31–7.

    Article  CAS  PubMed  Google Scholar 

  32. Schiff M, Levit S, Cohen-Moreno R. Childhood sexual abuse, post-traumatic stress disorder, and use of heroin among female clients in Israeli methadone maintenance treatment programs (MMTPS). Soc Work Health Care. 2010;49(9):799–813.

    Article  PubMed  Google Scholar 

  33. Lloyd JJ, Ricketts EP, Havens JR, Cornelius LJ, Bishai D, Huettner S, et al. The relationship between lifetime abuse and suicidal ideation in a sample of injection drug users. J Psychoactive Drugs. 2007;39(2):159–66.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Makin-Byrd K, Cronkite RC, Timko C. The influence of abuse victimization on attendance and involvement in mutual-help groups among dually diagnosed male veterans. J Subst Abuse Treat. 2011;41(1):78–87.

    Article  PubMed  Google Scholar 

  35. Schäfer I, Gromus L, Atabaki A, Pawils S, Verthein U, Reimer J, et al. Are experiences of sexual violence related to special needs in patients with substance use disorders? A study in opioid-dependent patients. Addict Behav. 2014;39(12):1691–4.

    Article  PubMed  Google Scholar 

  36. Gilmore AK, Walsh K, Frazier P, Ledray L, Acierno R, Ruggiero KJ, et al. Prescription opioid misuse after a recent sexual assault: a randomized clinical trial of a video intervention. Am J Addict. 2019;28(5):376–81.

    Article  PubMed  PubMed Central  Google Scholar 

  37. El-Bassel N, Gilbert L, Wu E, Go H, Hill J. Relationship between drug abuse and intimate partner violence: a longitudinal study among women receiving methadone. Am J Public Health. 2005;95(3):465–70.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Williams JR, Cole V, Girdler S, Cromeens MG. Exploring stress, cognitive, and affective mechanisms of the relationship between interpersonal trauma and opioid misuse. PLoS ONE. 2020;15(5): e0233185.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Garami J, Valikhani A, Parkes D, Haber P, Mahlberg J, Misiak B, et al. Examining perceived stress, childhood trauma and interpersonal trauma in individuals with drug addiction. Psychol Rep. 2019;122(2):433–50.

    Article  PubMed  Google Scholar 

  40. Williams JR, Girdler S, Williams W, Cromeens MG. The effects of co-occurring interpersonal trauma and gender on opioid use and misuse. J Interpers Violence. 2021;36(23–24):NP13185–205.

    Article  PubMed  Google Scholar 

  41. Kors SB. Child Maltreatment, Perceived Stress, and Opioid Use in Pregnancy. University of Tennesse. 2021

  42. Khoury L, Tang YL, Bradley B, Cubells JF, Ressler KJ. Substance use, childhood traumatic experience, and posttraumatic stress disorder in an urban civilian population. Depress Anxiety. 2010;27(12):1077–86.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Association AP. Diagnostic and statistical manual of mental disorders. 5th ed. American Psychiatric Association; 2013.

    Book  Google Scholar 

  44. Prins A, Bovin MJ, Smolenski DJ, Marx BP, Kimerling R, Jenkins-Guarnieri MA, et al. The primary care PTSD screen for DSM-5 (PC-PTSD-5): development and evaluation within a veteran primary care sample. J Gen Intern Med. 2016;31(10):1206–11.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Weathers F, Blake D, Schnurr P, Kaloupek D, Marx B, Keane T. The life events checklist for DSM-5 (LEC-5). 2013

  46. Diagnostic and statistical man-ual of mental disorders. 5 ed. Washington, DC: American Psychiatric Association; 2015

  47. Kiluk BD, Dreifuss JA, Weiss RD, Morgenstern J, Carroll KM. The Short inventory of problems - revised (SIP-R): psychometric properties within a large, diverse sample of substance use disorder treatment seekers. Psychol Addict Behav. 2013;27(1):307–14.

    Article  PubMed  Google Scholar 

  48. Moor A, Farchi M. Is rape-related self blame distinct from other post traumatic attributions of blame? A comparison of severity and implications for treatment. Women Ther. 2011;34(4):447–60.

    Article  Google Scholar 

  49. Bennice JA, Resick PA, Mechanic M, Astin M. The relative effects of intimate partner physical and sexual violence on post-traumatic stress disorder symptomatology. Violence Vict. 2003;18(1):87–94.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Gratz KL, Roemer L. Multidimensional assessment of emotion regulation and dysregulation: development, factor structure, and initial validation of the difficulties in emotion regulation scale: erratum. J Psychopathol Behav Assess. 2008;30:315.

    Article  Google Scholar 

  51. Messman-Moore TL, Bhuptani PH. A review of the long-term impact of child maltreatment on posttraumatic stress disorder and its comorbidities: an emotion dysregulation perspective. Clin Psychol Sci Pract. 2017;24(2):154.

    Article  Google Scholar 

  52. Walsh K, DiLillo D, Scalora MJ. The cumulative impact of sexual revictimization on emotion regulation difficulties: an examination of female inmates. Violence against women. 2011;17(8):1103–18.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Ullman SE, Peter-Hagene LC, Relyea M. Coping, emotion regulation, and self-blame as mediators of sexual abuse and psychological symptoms in adult sexual assault. J Child Sex Abus. 2014;23(1):74–93.

    Article  PubMed  Google Scholar 

  54. Weiss NH, Tull MT, Viana AG, Anestis MD, Gratz KL. Impulsive behaviors as an emotion regulation strategy: examining associations between PTSD, emotion dysregulation, and impulsive behaviors among substance dependent inpatients. J Anxiety Disord. 2012;26(3):453–8.

    Article  PubMed  PubMed Central  Google Scholar 

  55. Weiss NH, Tull MT, Sullivan TP, Dixon-Gordon KL, Gratz KL. Posttraumatic stress disorder symptoms and risky behaviors among trauma-exposed inpatients with substance dependence: the influence of negative and positive urgency. Drug Alcohol Depend. 2015;155:147–53.

    Article  PubMed  PubMed Central  Google Scholar 

  56. Weiss NH, Tull MT, Gratz KL. A preliminary experimental examination of the effect of emotion dysregulation and impulsivity on risky behaviors among women with sexual assault–related posttraumatic stress disorder. Behav Modif. 2014;38(6):914–39.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Cloitre M, Miranda R, Stovall-McClough KC, Han H. Beyond PTSD: Emotion regulation and interpersonal problems as predictors of functional impairment in survivors of childhood abuse. Behav Ther. 2005;36(2):119–24.

    Article  Google Scholar 

  58. Cloitre M, Koenen KC, Cohen LR, Han H. Skills training in affective and interpersonal regulation followed by exposure: a phase-based treatment for PTSD related to childhood abuse. J Consult Clin Psychol. 2002;70(5):1067.

    Article  PubMed  Google Scholar 

  59. Weiss NH, Kiefer R, Goncharenko S, Raudales AM, Forkus SR, Schick MR, et al. Emotion regulation and substance use: a meta-analysis. Drug Alcohol Depend. 2022;230: 109131.

    Article  PubMed  Google Scholar 

  60. Mandavia A, Robinson GG, Bradley B, Ressler KJ, Powers A. Exposure to childhood abuse and later substance use: indirect effects of emotion dysregulation and exposure to trauma. J Trauma Stress. 2016;29(5):422–9.

    Article  PubMed  PubMed Central  Google Scholar 

  61. Khantzian E. The self-medication hypothesis of addictive disorders: Focus on heroin and cocaine dependence. V DL Yalisove (ur.), Essential papers on addiction (str. 429–440). New York: New York University Press; 1985

  62. Gratz KL, Weiss NH, Tull MT. Examining emotion regulation as an outcome, mechanism, or target of psychological treatments. Curr Opin Psychol. 2015;3:85–90.

    Article  PubMed  PubMed Central  Google Scholar 

  63. Dworkin ER. Risk for mental disorders associated with sexual assault: a meta-analysis. Trauma Violence Abuse. 2020;21(5):1011–28.

    Article  PubMed  Google Scholar 

  64. Kilpatrick DG, Resnick HS, Milanak ME, Miller MW, Keyes KM, Friedman MJ. National estimates of exposure to traumatic events and PTSD prevalence using DSM-IV and DSM-5 criteria. J Trauma Stress. 2013;26(5):537–47.

    Article  PubMed  PubMed Central  Google Scholar 

  65. Brewin CR, Andrews B, Valentine JD. Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults. J Consult Clin Psychol. 2000;68(5):748.

    Article  CAS  PubMed  Google Scholar 

  66. Stanford MS, Greve KW, Dickens TJ Jr. Irritability and impulsiveness: relationship to self-reported impulsive aggression. Personality Individ Differ. 1995;19(5):757–60.

    Article  Google Scholar 

  67. Medeiros M, Carvalho LB, Silva TA, Prado LB, Prado GF. Sleep disorders are associated with impulsivity in school children aged 8 to 10 years. Arq Neuropsiquiatr. 2005;63:761–5.

    Article  PubMed  Google Scholar 

  68. Stautz K, Cooper A. Impulsivity-related personality traits and adolescent alcohol use: a meta-analytic review. Clin Psychol Rev. 2013;33(4):574–92.

    Article  PubMed  Google Scholar 

  69. Verdejo-García A, Bechara A, Recknor EC, Pérez-García M. Negative emotion-driven impulsivity predicts substance dependence problems. Drug Alcohol Depend. 2007;91(2–3):213–9.

    Article  PubMed  Google Scholar 

  70. Peck KR, Nighbor TD, Price M. Examining associations between impulsivity, opioid use disorder, and posttraumatic stress disorder: The additive relation between disorders. Exp Clin Psychopharmacol. 2022;30(5):486.

    Article  PubMed  Google Scholar 

  71. Ullman SE. Mental health services seeking in sexual assault victims. Women Ther. 2007;30(1–2):61–84.

    Article  Google Scholar 

  72. Gilmore AK, Leone RM, Oesterle DW, Davis KC, Orchowski LM, Ramakrishnan V, et al. Web-based alcohol and sexual assault prevention program with tailored content based on gender and sexual orientation: preliminary outcomes and usability study of positive change (+ change). JMIR formative research. 2022;6(7): e23823.

    Article  PubMed  PubMed Central  Google Scholar 

  73. Elliott DE, Bjelajac P, Fallot RD, Markoff LS, Reed BG. Trauma-informed or trauma-denied: principles and implementation of trauma-informed services for women. J Community Psychol. 2005;33(4):461–77.

    Article  Google Scholar 

  74. Hedtke KA, Ruggiero KJ, Fitzgerald MM, Zinzow HM, Saunders BE, Resnick HS, et al. A longitudinal investigation of interpersonal violence in relation to mental health and substance use. J Consult Clin Psychol. 2008;76(4):633.

    Article  PubMed  Google Scholar 

  75. Walsh K, Resnick HS, Danielson CK, McCauley JL, Saunders BE, Kilpatrick DG. Patterns of drug and alcohol use associated with lifetime sexual revictimization and current posttraumatic stress disorder among three national samples of adolescent, college, and household-residing women. Addict Behav. 2014;39(3):684–9.

    Article  PubMed  Google Scholar 

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Acknowledgements

Not applicable.

Funding

This research was supported by the Center for Biomedical Research and Excellence (COBRE) on Opioids and Overdose funded by the National Institute on General Medical Sciences (P20 GM125507). Work on this paper by the third author (SRF) was supported by the National Institute on Drug Abuse Grant F31 DA051167.

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Authors and Affiliations

  1. Department of Adult Psychiatry, Rhode Island Hospital, Providence, RI, USA

    Prachi H. Bhuptani & Lindsay M. Orchowski

  2. Department of Psychiatry and Human Behavior, Brown University Medical School, Providence, RI, USA

    Prachi H. Bhuptani & Lindsay M. Orchowski

  3. Department of Psychology, University of Rhode Island, 142 Flagg Rd., Kingston, RI, USA

    Shannon R. Forkus, Noam G. Newberger & Nicole H. Weiss

  4. Medical University of South Carolina, Charleston, SC, USA

    Shannon R. Forkus

Authors
  1. Prachi H. Bhuptani
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  2. Lindsay M. Orchowski
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  3. Shannon R. Forkus
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  4. Noam G. Newberger
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  5. Nicole H. Weiss
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Contributions

PHB was involved in the conceptualization of the study, data analysis, and writing. LMO was involved in study conceptualization and writing. SRF was involved in data analysis and reviewing and editing the manuscript. NGN was involved in data analysis and reviewing and editing the manuscript. NHW was involved in study conceptualization, data analysis, and writing. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Nicole H. Weiss.

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The study received approval from the University of Rhode Island’s Institutional Review Board (IRB1819-249). All participants consented to participate in the study.

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The authors declare that they have no competing interests.

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Bhuptani, P.H., Orchowski, L.M., Forkus, S.R. et al. The impact of exposure to physical and sexual violence on opioid consequences among trauma-exposed individuals recruited from the community who use opioids. Harm Reduct J 20, 167 (2023). https://doi.org/10.1186/s12954-023-00901-y

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Keywords

Harm Reduction Journal

ISSN: 1477-7517