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Table 1 Clinical data

From: Opioid tolerance in methadone maintenance treatment: comparison of methadone and levomethadone in long-term treatment

Clinical dataa

Substance

Statistic

Methadone

Levomethadone

p value

(N = 370)

(N = 309)

Age (years)

 18–20

6 (1.6)

1 (0.3)

0.474c; Χ = 0.54

 21–30

84 (22.7)

65 (21.0)

 31–40

102 (27.6)

87 (28.2)

 41–50

135 (36.5)

117 (37.9)

 51–60

35 (9.5)

37 (12.0)

 61–70

8 (2.2)

2 (0.6)

Sex

 Male

275 (75.3)

203 (65.7)

0.006; Χ = 7.5

 Female

90 (24.7)

106 (34.3)

Years of education mean ± SD

10.3 ± 1.7

10.4 ± 1.4

0.751; T = −.32

Years of methadone maintenance treatment mean ± SD

6.8 ± 5.6

8.3 ± 6.2

0.002; T = −3.2

Years of dependency

 ≤1

1 (0.3)

3 (1.1)

1.0b; Χ = 0.007

 ≥1–3

9 (2.7)

9 (3.2)

 ≥3–5

25 (7.6)

15 (5.3)

 ≥5–10

68 (20.6)

39 (13.8)

 ≥10

227 (68.8)

216 (76.6)

Continued use of illegal drugs despite MMT

226 (63.8)

205 (67.9)

0.285; Χ = 1.2

Continued use of multiple illegal drug despite MMT

82 (23.6)

81 (27.6)

0.275; Χ = 1.3

Methadone dose/methadone equivalent (mg)b mean ± SD

90.0 ± 41.3

99.1 ± 46.9

0.007; T = −2.7

Imprisonment in the past

212 (60.7)

176 (59.1)

0.688; Χ = 1.9

Withdrawal treatment in the past

172 (50.0)

159 (53.5)

0.372; X = 0.8

Comorbid psychiatric disordere

90 (26.4)

99 (33.3)

0.06; X = 3.7

Chronic infection

180 (52.2)

144 (48.2)

0.31; X = 1.0

 HIV

18 (5.2)

25 (8.3)

0.117; X = 2.5

 Hepatits C

163 (47.2)

124 (41.5)

0.141; X = 2.1

 Hepatitis B

25 (7.2)

27 (9.0)

0.407; X = 0.6

 Lues

1 (0.3)

2 (0.7)

0.483; X = 0.5

  1. aData shown as N (%) if not otherwise specified. Out of the 679 patients who specified type of substance, dosage, and duration of MMT, some patients did not gave information concerning further data: 5 concerning gender, 67 concerning duration of dependence, 31 concerning detoxification therapies, 23 concerning continued use of illegal drugs, 42 concerning continued use of multiple illegal drugs, and 32 concerning imprisonment
  2. bDosage of levomethadone was calculated into equivalent methadone dosage
  3. cChi-square for group ≤30 versus >30 age (years)
  4. dChi-square for group ≤5 versus >5 years of dependency
  5. eMultiple answers were possible. Comorbid psychiatric disorders reported N > 5: depression N = 108; psychotic disorder and schizophrenia N = 13; anxiety disorders N = 30; personality disorder N = 39; and ADHD N = 10