The acceptability and feasibility of a brief psychosocial intervention to reduce blood-borne virus risk behaviours among people who inject drugs: a randomised control feasibility trial of a psychosocial intervention (the PROTECT study) versus treatment as usual

Gilchrist, Gail; Swan, Davina; Shaw, April; Keding, Ada; Towers, Sarah; Craine, Noel; Munro, Alison; Hughes, Elizabeth; Parrott, Steve; Strang, John; Taylor, Avril; Watson, Judith

doi:10.1186/s12954-017-0142-5

Harm Reduction Journal

Table 4 Summary of mean group differences for outcome measuresⁱ

From: The acceptability and feasibility of a brief psychosocial intervention to reduce blood-borne virus risk behaviours among people who inject drugs: a randomised control feasibility trial of a psychosocial intervention (the PROTECT study) versus treatment as usual

		Analysis by randomised groups (ITT)			Analysis by attendance of at least one intervention session
		Mean	95% CI	80% CI	Mean	95% CI	80% CI
Injecting risk practices^a	End of intervention	−0.45	−1.50 to 0.61	−1.14 to 0.24	−0.52	−1.78 to 0.74	−1.35 to 0.30
Injecting risk practices^a	1 month post-intervention	−0.25	−1.33 to 0.82	−0.96 to 0.45	−0.25	−1.51 to 1.01	−1.08 to 0.57
Sexual risk behaviours^b	End of intervention	0.57	−0.20 to 1.34	0.06 to 1.07	0.08	−0.85 to 1.02	−0.53 to 0.70
Sexual risk behaviours^b	1 month post-intervention	1.26	0.43 to 2.08	0.71 to 1.80	0.13	−0.80 to 1.06	−0.48 to 0.74
Self-efficacy^c	End of intervention	1.17	−0.71 to 3.05	−0.06 to 2.40	2.20	0.02 to 4.38	0.77 to 3.62
Self-efficacy^c	1 month post-intervention	0.08	−1.90 to 2.07	−1.22 to 1.38	1.65	−0.51 to 3.82	0.24 to 3.07
HIV transmission knowledge^d	End of intervention	−0.06	−0.88 to 0.75	−0.60 to 0.47	0.04	−0.91 to 0.99	−0.58 to 0.66
HIV transmission knowledge^d	1 month post-intervention	0.18	−0.70 to 1.06	−0.39 to 0.76	−0.07	−1.00 to 0.87	−0.68 to 0.55
HCV transmission knowledge^e	End of intervention	0.16	−1.37 to 1.68	−0.84 to 1.15	2.13	0.41 to 3.85	1.01 to 3.26
HCV transmission knowledge^e	1 month post-intervention	0.12	−1.52 to 1.75	−0.96 to 1.19	0.30	−1.40 to 1.99	−0.81 to 1.41
HBV transmission knowledge^f	End of intervention	0.79	−0.31 to 1.89	0.07 to 1.51	0.79	−0.51 to 2.08	−0.06 to 1.63
HBV transmission knowledge^f	1 month post-intervention	0.75	−0.41 to 1.91	−0.01 to 1.51	0.88	−0.41 to 2.18	0.03 to 1.73
Withdrawal prevention^g	End of intervention	0.28	−1.37 to 1.93	−0.80 to 1.36	0.38	−1.54 to 2.31	−0.88 to 1.64
Withdrawal prevention^g	1 month post-intervention	1.41	−0.34 to 3.17	0.26 to 2.57	1.83	−0.10 to 3.76	0.57 to 3.09
Motivation to change (for self)^h	End of Intervention	−0.20	−0.47 to 0.07	−0.38 to −0.03	−0.21	−0.52 to 0.09	−0.42 to −0.01
Motivation to change (for self)^h	1 month post-intervention	−0.01	−0.30 to 0.28	−0.20 to 0.18	−0.21	−0.51 to 0.10	−0.41 to −0.01
Motivation to change (for others)^h	End of intervention	−0.40	−0.67 to-0.13	−0.58 to −0.22	−0.53	−0.84 to −0.23	−0.73 to −0.33
Motivation to change (for others)^h	1 month post-intervention	−0.14	−0.43 to 0.15	−0.33 to 0.05	−0.29	−0.59 to 0.01	−0.49 to −0.10

^aRange: 0–9 (higher number = more risk events)
^bRange: 0–7 (higher number = more risk behaviours)
^cRange: 8–32 (higher score = greater self-efficacy)
^dRange: 0–14 (higher score = better knowledge)
^eRange: 0–31 (higher score = better knowledge)
^fRange: 0–15 (higher score = better knowledge)
^gRange: 0–20 (higher score = better prevention tactics)
^hRange: 0–5 (higher score = more motivation)
ⁱMean differences represent the estimated mean group difference following regression analysis adjusted for outcome at baseline, gender and recruitment site; Positive mean difference = higher score in the intervention arm, negative mean difference = higher score in the control arm

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