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Table 2 Toxicity classification calculations for each flavouring compound using the maximum concentrations reported by Vardavas et al.

From: Toxicity classification of e-cigarette flavouring compounds based on European Union regulation: analysis of findings from a recent study

SubstanceHazard categoryReported max concentration
(% w/w)*
Calculated ATEmixATEmix limit or min concentration for toxicity classification% difference**
MentholΗ315 Category 20.4991 10− 95.0%
Η319 Category 20.4991 10− 95.0%
Ethyl maltolΗ302 Category 47.0967046≤ 2000− 71.6%
LinaloolΗ315 Category 20.263 10− 97.4%
Η317 Category 10.263 1− 73.7%
Η319 Category 20.263 10− 97.4%
Methyl cyclopentenoloneΗ302 Category 42.506719,946≤ 2000− 90.0%
Η319 Category 22.5067 10− 74.9%
Η334 Category 12.5067 1150.7%
Η335 Category 32.5067 20− 87.5%
β-DamasconeΗ317 Category 10.0742 1− 92.6%
Η411 Category 20.0742 25− 99.7%
Ethyl vanillinΗ302 Category 40.913554,734≤ 2000− 96.3%
Η315 Category 20.9135 10− 90.9%
Η319 Category 20.9135 10− 90.9%
Η335 Category 30.9135 20− 95.4%
Η412 Category 30.9135 25− 96.3%
β-IononeΗ400 Category 10.0076 25> − 99.9%
Η411 Category 20.0076 25> − 99.9%
Acetyl pyrazineΗ315 Category 20.1067 10− 98.9%
Η319 Category 20.1067 10− 98.9%
Η335 Category 30.1067 20− 99.5%
α-IononeΗ334 Category 10.012 1− 98.8%
Η412 Category 30.012 25> − 99.9%
2,5 DimethylpyrazineΗ302 Category 40.01972,538,071≤ 2000− 99.9%
α-DamasconeΗ302 Category 40.00786,410,256≤ 2000> − 99.9%
Η317 Category 10.0078 1− 99.2%
Η411 Category 20.0078 25> − 99.9%
3,4 Dimethoxy-benzaldehydeΗ302 Category 40.03591,392,757≤ 2000− 99.9%
LimoneneΗ304 Category 10.0001 10> − 99.9%
Η315 Category 20.0001 10> − 99.9%
Η317 Category 10.0001 1> − 99.9%
Η400 Category 10.0001 25> − 99.9%
Η410 Category 10.0001 25> − 99.9%
  1. *Maximum concentrations reported by Vardavas et al
  2. **Percent difference between the maximum concentration reported by Vardavas et al. and the concentration needed to be classified as toxic
  3. Italics represents the compound and hazard exceeding the limits for toxicity classification