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Table 1 Dextroamphetamine sulfate dosing: guidance and dose received by presented case

From: Use of sustained release dextroamphetamine for the treatment of stimulant use disorder in the setting of injectable opioid agonist treatment in Canada: a case report

  Days 1–3 Days 4–7 Days 8–14 Days 15–21 Days 22–28
Clinic protocol (mg) Case received (mg) Clinic protocol (mg) Case received (mg) Clinic protocol (mg) Case received (mg) Clinic protocol (mg) Case received (mg) Clinic protocol (mg) Case received (mg)
Daily Dose 1 15 15 15 15 30** 30 45*** 30 60**** 30
Daily Dose 2 15* 15 30** 30 45*** 30 60**** 30
  1. This table reflects the dosing protocol followed at the clinic where the patient received this treatment. He tolerated and remained at 30 mg twice per day
  2. Tolerance is determined based on absence of adverse events, and patient reported therapeutic effect, in line with patient-reported goals
  3. Start at 15 mg (or lower if determined to be more suitable (i.e. 10 mg capsules are available)). Increase incrementally as needed, every week or so. There is not usually any urgency and patients generally take some time to assess effect and tolerance. Table reflects general guidance, not all clients will need or want to reach 60 mg twice per day
  4. Patients are dispensed dextroamphetamine from the clinic’s on-site pharmacy. The pharmacy hours are 7:30am-5:30 pm. Patients can take their first dextroamphetamine dose as early as 7:30am. The second dose can be taken anytime following the first dose, so long as four hours have passed between doses
  5. *If dose 1 tolerated on days 1–3 **If dose 1, 2 tolerated on days 4–7
  6. ***If doses 1, 2 tolerated on days 8–14 ****If doses 1, 2 tolerated on days 15–21