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Table 1 Characteristics of Participants with High vs With Non-high Intention to Get Naloxone (N = 549)

From: Intention to get naloxone among patients prescribed opioids for chronic pain

Characteristics

n (%)

P valuea

Total participants (N = 549)

Non-high intention (n = 382 [69.58%])

High intention (n = 167 [30.42%])

Demographics

Age

18–35 years

153 (27.87)

92 (24.08)

61 (36.53)

 < .0001

36–55 years

287 (52.28)

188 (49.21)

99 (59.28)

 > 55 years

109 (19.85)

102 (26.70)

7 (4.19)

Race 

White or Caucasian

459 (83.61)

315 (82.46)

144 (86.23)

0.5478

Black or African American

55 (10.02)

41 (10.73)

14 (8.38)

Other Racial Group1

35 (6.38)

26 (6.81)

9 (5.39)

Ethnicity 

Hispanic

68 (12.39)

37 (9.69)

31 (18.56)

0.0037

Non-Hispanic

481 (87.61)

345 (90.31)

136 (81.44)

Gender

Male

258 (46.99)

139 (36.39)

119 (71.26)

 < .0001

Female

291(53.01)

243 (63.61)

48 (28.74)

Education level

Less than high school or high school

176 (32.06)

156 (40.84)

20 (11.98)

 < .0001

Undergraduate level

159 (28.96)

124 (32.46)

35 (20.96)

Graduate level or above

214 (38.98)

102 (26.70)

112 (67.07)

Marital status

Married

336 (61.20)

204 (53.40)

132 (79.04)

 < .0001

Unmarried or other status2

213 (38.80)

178 (46.60)

35 (20.96)

Employment status 

Employed Full time

298 (54.28)

163 (42.67)

135 (80.84)

 < .0001

Employed part time or other status3

251 (45.72)

219 (57.33)

32 (19.16)

Insurance

Employment-Based or Direct Purchase Private

254 (46.27)

168 (43.98)

86 (51.50)

0.0656

Medicare/Medicaid

257 (46.81)

182 (47.64)

75 (44.91)

VA or CHAMPVA or uninsured

38 (6.92)

32 (8.38)

6 (3.59)

Household income before taxes

Less than $25,000

88 (16.03)

73 (19.11)

15 (8.98)

 < 0.0001

$25,000—$74,999

193 (35.15)

162 (42.41)

31 (18.56)

$75,000 to $99,999

78 (14.21)

55 (14.40)

23 (13.77)

$100,000 to $149,999

105 (19.13)

54 (14.14)

51 (30.54)

$150,000 or more

85 (15.48)

38 (9.95)

47 (28.14)

Living area

Urban

244 (44.44)

122 (31.94)

122 (73.05)

 < 0.0001

Suburban

199 (36.25)

167 (43.72)

32 (19.16)

Rural

106 (19.31)

93 (24.35)

13 (7.78)

Characteristics of Opioid Overdose Risk Factors

Condition History

Chronic obstructive pulmonary disease

Yes

229 (41.71)

103 (26.96)

126 (75.45)

 < 0.0001

No

320 (58.29)

279 (73.04)

41 (24.55)

Obstructive sleep apnea

Yes

240 (43.72)

111 (29.06)

129 (77.25)

 < 0.0001

No

309 (56.28)

271 (70.94)

38 (22.75)

Non-opioid substance use disorder4

Yes

227 (41.35)

100 (26.18)

127 (76.05)

 < 0.0001

No

322 (58.65)

282 (73.82)

40 (23.95)

Mental health disorders5

Yes

328 (59.74)

194 (50.79)

134 (80.24)

 < 0.0001

No

221 (40.26)

188 (49.21)

33 (19.76)

Cancer

Yes

128 (23.32)

52 (13.61)

76 (45.51)

 < 0.0001

No

421 (76.68)

330 (86.39)

91 (54.49)

Pain Assessment and Opioid Pain Medication Use

Chronic Pain Assessment

Pain at its worst in the last week

Severe pain6

432 (78.69)

290 (75.92)

142 (85.03)

0.0164

Non-severe pain

117 (21.31)

92 (24.08)

25 (14.97)

Pain at its least in the last week

Severe pain6

285 (51.91)

160 (41.88)

125 (74.85)

 < 0.0001

Non-severe pain

264 (48.09)

222 (58.12)

42 (25.15)

Pain on the average

Severe pain6

336 (61.20)

203 (53.14)

133 (79.64)

 < 0.0001

Non-severe pain

213 (38.80)

179 (46.86)

34 (20.36)

Pain right now

Severe pain6

303 (55.19)

180 (47.12)

123 (73.65)

 < 0.0001

Non-severe pain

246 (44.81)

202 (52.88)

44 (26.35)

Opioid pain medications frequency

 < 1 time per month

47 (8.56)

24 (6.28)

23 (13.77)

 < 0.0001

1–4 times per month

133 (24.23)

86 (22.51)

47 (28.14)

1–2 days per week

121 (22.04)

73 (19.11)

48 (28.74)

Near daily or daily

233 (42.44)

199 (52.09)

49 (29.34)

Benzodiazepines use

Yes

300 (54.64)

151 (39.53)

149 (89.22)

 < 0.0001

No

249 (45.36)

231 (60.47)

18 (10.78)

Characteristics of Knowledge about Naloxone

Heard about naloxone before

Yes

266 (48.45)

144 (37.70)

122 (73.05)

 < 0.0001

No

283 (51.55)

238 (62.30)

45 (26.95)

Received counseling on naloxone

Yes

173 (31.51)

55 (14.40)

118 (70.66)

 < 0.0001

No

376 (68.49)

327 (85.60)

49 (29.34)

Who counseled you on naloxone (n = 173)

Only Physician

61 (35.26)

23 (41.82)

38 (32.20)

0.0301

Only Pharmacist

37 (21.39)

16 (29.09)

21 (17.80)

More than 2 health providers

75 (43.35)

343 (29.09)

108 (50.00)

Had ever been offered naloxone

Yes

187 (34.06)

61 (15.97)

126 (75.45)

 < 0.0001

No

362 (65.94)

321 (84.03)

41 (24.55)

Who offered you a naloxone prescription(n = 187)

Doctor who prescribed your opioid pain medication

131 (70.05)

40 (65.57)

91 (72.22)

0.1073

Another doctor

34 (18.18)

16 (26.23)

18 (14.29)

Pharmacist

22 (11.76)

5 (8.2)

17 (13.49)

Did you fill the naloxone prescription (n = 187)

Yes

164 (87.70)

46 (75.41)

118 (93.65)

0.0004

No

23 (12.30)

15 (24.59)

8 (6.35)

What, if any, difficulties did you have filling the naloxone prescription(n = 187)

Only Pharmacy did not stock it

34 (18.18)

7 (11.48)

27 (21.43)

 < 0.0001

Only Problem with insurance coverage

59 (31.55)

24 (39.34)

35 (27.78)

Only Pharmacist didn’t know what it was

34 (18.18)

22 (36.07)

12 (9.52)

More than 2 above reasons

60 (32.09)

8 (13.11)

52 (41.27)

Willingness to pay for naloxone

Unwilling7

69 (12.57)

66 (17.28)

3 (1.8)

 < 0.0001

Willing7

480 (87.43)

316 (82.74)

164 (98.2)

  1. The questions in italics are shown among the subgroup of patients who responded yes
  2. VA veteran administration insurance, CHAMPVA The civilian health and medical program of the department of veterans affairs
  3. aP values are from Pearson χ2 tests of association for the comparison for all baseline characteristics in terms of having high intention vs non-high intention. Significance at P < 0.05
  4. 1Includes Asian or Asian American, American Indian and Alaska Native, Native Hawaiian or Pacific Islander
  5. 2Includes Widowed, Divorced, Separated
  6. 3Includes employed part time, unemployed looking for work, unemployed not looking for work, tired, student, homemaker, self-employed, unable to work
  7. 4Includes Alcohol use disorder, Tobacco use disorder, Cannabis use disorder, Stimulant use disorder, Hallucinogen use disorder
  8. 5Includes Anxiety disorder, Mood disorder, Schizophrenia and psychotic disorder, Dementia, Eating disorder, Other mood disorder
  9. 6Severe pain is defined as score ≥ 7
  10. 7Unwilling includes strongly unwilling, unwilling, somewhat unwilling, and neither willing nor willing; Willing includes somewhat willing, willing, and strongly willing