Table 1 Characteristics of PWUD with chronic hepatitis C and factors associated with DAA uptake, univariable and multivariable Cox regression (ANRS FANTASIO study; 22,615 patients)
Variables | N (%) or | Univariable analyses | Multivariable analysis | ||
|---|---|---|---|---|---|
Mean (SD) at inclusion | HR [95% CI] | p-value | aHR [95% CI] | p-value | |
Sex | |||||
Male (ref.) | 17,682 (78.2) | 1 | 1 | ||
Female | 4933 (21.8) | 0.79 [0.72–0.86] | < 0.001 | 0.82 [0.75–0.90] | < 0.001 |
Age (per 1-year increase) | 46.4 (7.3) | 1.04 [1.03–1.05] | < 0.001 | 1.03 [1.03–1.04] | < 0.001 |
Receiving CMU-C | |||||
No (ref.) | 16,119 (71.3) | 1 | 1 | ||
Yes | 6496 (28.7) | 0.82 [0.76–0.88] | < 0.001 | 0.91 [0.84–0.98] | 0.018 |
Liver disease severity | |||||
No cirrhosis and no liver cancer (ref.) | 21,650 (95.7) | 1 | 1 | ||
Cirrhosis without liver cancer | 776 (3.4) | 4.33 [3.83–4.90] | < 0.001 | 3.99 [3.50–4.54] | < 0.001 |
Liver cancer | 189 (0.8) | 3.78 [2.85–5.03] | < 0.001 | 3.04 [2.27–4.06] | < 0.001 |
Alcohol use disorder (AUD) | |||||
No AUD (ref.) | 18,247 (80.7) | 1 | 1 | ||
Untreated AUD | 3445 (15.2) | 1.06 [0.96–1.17] | 0.224 | 0.92 [0.83–1.01] | 0.090 |
Treated AUD | 923 (4.1) | 1.08 [0.91–1.27] | 0.369 | 1.06 [0.89–1.26] | 0.505 |
Adherence to OAT* | |||||
Less than 20% (ref.) | 17,224 (76.2) | 1 | 1 | ||
20% and more | 5391 (23.8) | 1.28 [1.19–1.38] | < 0.001 | 1.28 [1.18–1.38] | < 0.001 |
Adherence to OAT* | |||||
0% (ref.) | 13,081 (57.8) | 1 | |||
1–19% | 4143 (18.3) | 0.94 [0.86–1.03] | 0.205 | – | – |
20–39% | 2126 (9.4) | 1.35 [1.21–1.51] | < 0.001 | ||
40–59% | 1077 (4.8) | 1.37 [1.19–1.57] | < 0.001 | ||
60% + | 2188 (9.7) | 1.12 [0.99–1.26] | 0.069 | ||