Prevalence of skin problems and leg ulceration in a sample of young injecting drug users

Sample

Drug use has its own subcultures and users often educate peers within their own geographical areas, and actual injecting practices can vary from suburb to suburb. A wide geographic sample even within one city, therefore, was important to ensure variations due to locality were captured. Participants were recruited from eight different venues (needle exchanges and methadone clinics) in the north, south, east and west of Glasgow. These venues were selected as they were where the highest numbers of injecting drug users were known to engage with services in each direction of the city and where a private room was available for interviewing. A convenience sample was selected as this is a challenging population to investigate because many drug users are transiently accommodated, frequently incarcerated and engaged in chaotic lifestyles, which means arranging appointments for interview or follow-up can be difficult or impossible, and a sampling frame could not therefore be used [43, 44, 6]. The approach to recruitment was similar to that of other local studies which had successfully overcome many of the traditional problems of recruitment of drug users [45].

Inclusion/exclusion criteria

In Scotland alone, it is thought that the number of individuals with problem drug use is nearly 60,000. Glasgow has the highest rate of problematic drug use in Scotland, with prevalence rates remaining consistent in the last 5 years and thought to be around 13,900 individuals. The majority of drug users are aged between 15 and 64 years, with the greatest proportion in the 35–64-year age group [46]. The prevalence of injecting drug use is not currently known, although older studies have been published [47].

The research aimed to capture people like these described, whilst avoiding the challenges of working with children. Participants over the age of 44 years were excluded to attempt to reduce the potential results created by the impact of age-related disease on ulcer development. Leg ulcer studies of a wider population will tend to include from age 50 years of age or over [42], so 44 years was considered to be a safe margin.

The sample included individuals with a current or previous history of injecting drug use, aged 16 to 44 years, who could understand and speak English. Participants were excluded if they did not meet the inclusion criteria or did not appear to be able to either understand what they are consenting to take part in or answer questions, including being visibly under the influence of drugs or alcohol. Staff at the recruitment venues who were often familiar with individual participants also helped identify and exclude those who were not fit to consent at that time [48].

Recruitment

Posters and leaflets describing the study were displayed in each venue for at least 2 weeks prior to recruitment commencing. During recruitment, individuals were approached by the researcher as they entered each venue and asked if they would be interested in taking part in a research study and answering some questions about injecting and complications. Informed consent was obtained and the interviews lasted an average of 20 min.

A pilot study was undertaken earlier to test recruitment, data collections tools and analysis which informed the method. Ethical and governance approval was sought and obtained from NHS Greater Glasgow and Clyde to undertake the study.

The study was conducted over a period of 3 months at the end of 2008.

Data collection

Interviews were conducted across the eight venues in the north, south, east and west of the city. Participants provided initials and date of birth, together with the first few letters of their postcode—this allowed any duplicate interviews to be identified.

All interviews were conducted by one researcher, and participants were given an honorarium of a £2 shopping voucher as an acknowledgement of their time taken to participate.

A total of 204 interviews were conducted. On three occasions, participants who the researcher thought had been interviewed before were adamant they had not previously been interviewed. The researcher felt obliged to conduct a second interview. When initials and dates of birth were checked, the three interviewees were found to be duplicates. The participants knew of the incentive/honorarium and may have wished to collect another £2 voucher. The data from these second three interviews were removed from the database. A fourth interview was abandoned midway, and the incomplete data from the fourth interview were also removed and not included in the analysis. The analysis was conducted on the remaining 200 interviews.

Data analysis

All data were entered into SPSS version 15.0 and checked independently for accuracy. All identifiers were removed after checking. Data were analysed using descriptive and inferential statistics. The confidence interval for all tests was 95%. The data were reviewed for missing values and there were none.

Sample

Of the current injectors, 20% were long-term injectors (n = 26), who had been injecting for 20 years or more.

In response to the question ‘Have you ever had a skin problem?’, 60% (n = 120) said yes and 40% said no (n = 80). The majority of these were male (72%, n = 86; females 28%, n = 34).

The majority of the current (63%, n = 80) and over half of the former (55%, n = 40) injectors reported a problem with the skin. Almost all of the long-term injectors (>20 years) reported a problem with their skin (85%, n = 22).

A Mann-Whitney U test comparing groups of those that had injected for less than a year, 1–5 years, 6–10 years, 11–20 years and over 20 years showed that those who injected for longer experienced more skin problems (U = 2,896, z = −4.89, p = ≤0.001), indicating that the longer a person injects, the more likely they are to have a skin problem.Although 60 participants had never had skin problems, 74 (62%) of the participants reporting skin problems experienced more than one type of problem (Figure 1).

The majority of those who reported skin problems complained of abscesses (75%, n = 90), followed by lumps (48%, n =58) and track marks (47%, n =56), followed by leg ulcers (25%, n = 30) acid burns (24%, n = 29) and chronic wounds other than leg ulcers (23%). Eight per cent complained of other skin problems, and these were scarring (n =3), bruising (n =2), varicose veins (n =2), phlebitis (n =1), cellulitis (n =1), phlebitis (n = 1), necrotising fasciitis (n =1), haematoma (n =1) and thin skin (n = 1).

In response to the question ‘Have you ever had a leg ulcer?’, 25% (n =30) of those reporting skin problems said yes; of these, 47% (n =14) had active ulceration at the time of the interview. Therefore, the prevalence of active leg ulceration within the 200 participants was 7% (14/200) and lifetime prevalence was 15% (30/200). Eighteen per cent (n = 13/73) of the former injectors and a total of 13% (n = 17/127) of the current injectors had suffered leg ulceration.

A higher percentage of females had leg ulceration (17%, n = 9/52) than men (14%, n = 21/148). Of those with a leg ulcer, 6 ulcers had never healed, 12 ulcers had healed up and broken down/recurred again and 12 ulcers had healed up at the time of the research.

Sample

The socio-demographic profile of Glaswegian drug injectors is known to be two-thirds male, typically unemployed and aged about 30 years, and mostly using heroin [53–55]. The sample in this study was similar in that the majority of participants were male with a comparable mean age.

There were no participants under the age of 21 years, and no one was excluded on the basis that they were too young to participate. This may indicate that injecting in this younger age group is low and so skin problems may be small or non-existent or that the services used for recruitment were not engaging with younger drug users and so this figure may not be indicative of skin problems in younger injectors.

Skin problems

One hundred twenty participants reported skin problems, giving a prevalence of 60%. The majority complained of abscesses (75%), lumps (48%) and track marks (47%), followed by leg ulcers (25%), acid burns (24%) and chronic wounds other than leg ulcers (23%). Eight per cent complained of other skin problems over the duration of their injecting careers including bruising and varicose veins, phlebitis, cellulitis, haematoma, scarring and thin skin.

These findings indicate that a large proportion has experienced abscesses and soft tissue infection. This is unsurprising given that the injection process will not be a sterile procedure and the drugs injected are often cut and mixed with unsterile materials; nevertheless, the prevalence is extremely high.

Any injecting injury is frequently referred to as an abscess by both service users and staff. Similarly, within the medical literature, soft tissue/bacterial infection is the main injecting problem described [56]. Whilst there is no denying that infection is a common sequela to injecting illicit materials, this is a misrepresentation of the problem.

Traditionally, abscesses may be defined as ‘a localised collection of pus’ [57]. However, many papers commonly use the term abscess to describe any kind of red raised lump. This is confusing and possibly harmful. Many missed ‘hits’ (injections) also appear as red lumps and can be misnamed abscesses. The injection may miss the vein, or puncture the vein, allowing fluid to escape into the tissues. They tend not to be pus filled, hot, or with spreading cellulitis; however, they may take some time to resolve but are not infected and do not require antibiotics [58]. The abscesses may require treatment with antibiotics, but overuse or inappropriate use of antibiotics can lead to resistance and other unwanted side effects [13].

However, appropriate assessment of skin problems and injecting injuries is important as misdiagnosis can have serious implications. Skin breakdown may be the first sign of problematic drug use. Beeching and Crowcroft [59], in their overview of tetanus in injecting drug users (IDUs), warn clinicians of systemic effects of apparently trivial wound infections in IDUs when they present with collapse, sepsis or odd neurological symptoms which might otherwise be dismissed as direct results of drug intoxication. Seemingly innocuous lesions can also indicate far more serious systemic disease (e.g. anthrax, wound botulism, clostridia [60, 4, 61]), and skin problems must not be viewed in isolation and should be part of a systemic assessment of other signs and symptoms such as fever and flu-like illness. It is normal for the body to respond with a temporary inflammatory response to injury, but what is more difficult is detecting the difference between normal inflammation and an inflammatory process which may indicate something more serious and systemic occurring.

Existing guidance errs very much on the side of caution, which, although correct, demonstrates the difficulty in differentiating between lesions, and partly why definition is so important [62]. Clearer guidance is needed for both health professionals and drug users on skin problems.

Leg ulceration

The findings revealed a high prevalence of leg ulceration in the sample population of young injecting drug users. Fifteen per cent of the sample population had experienced a chronic leg ulcer, defined as ‘a break in the skin between the knee and the ankle that was present four weeks or more’ [63], whilst 7% had an active ulcer at the time of interview. Comparatively, within the general population, it is known that 1% of the adult populations (within Western countries) are likely to have a chronic leg ulcer at some time [64]. Later studies have agreed with this figure [65, 66], and therefore, the prevalence of leg ulceration within an injecting population is worryingly high. This figure, of 15% prevalence, verifies the anecdotal claims from community nursing practitioners who are seeing rising numbers of young people with leg ulceration in their clinical practice but have little empirical evidence to support their assertion [67].

This finding is of concern as once ulceration occurs, the long-term impact on health services may become onerous. The ulcerations in the study were occurring in younger people than those who traditionally form the 1% of the population that experience leg ulceration. Generally, this is a disease of old age and prevalence is known to increase with age [68]. Whilst considered a disease of the elderly population, it is not rare to develop ulceration before middle age. Work by Mackenzie et al. [69] identified that in a sample of 118 patients with leg ulceration, 46% had had developed ulceration before the age of 50 years and were more likely to be male and obese and to have a history of DVT and/or long bone fracture. In mainstream studies of leg ulceration, it is possible that injecting drug use is not considered as a risk factor, especially if illicit use is hidden for example in femoral injectors [70].

However, if younger people are increasingly experiencing leg ulceration, then the impact on health services will be pronounced as recurrence occurs and as sufferers age. Leg ulceration is end-stage venous disease [34] and a chronic recurrent condition which is costly, not just in terms of treatment but long-term prevention of recurrence and also in terms of human suffering [71]. The ulcers can be painful, malodorous and debilitating, badly impacting on quality of life and costly to treat [72–74]. The impact on younger people may arguably be more severe, preventing normal activities and possibly even employment, and the ulceration may affect lives long after drug use has ceased [75].

Treatment for venous ulcers in a more elderly population consists of regular and frequent intervention, usually with specialised compression therapy requiring expert nursing staff and considerable time to achieve healing. Generally, compression bandaging is followed with long-term compression hosiery. Frequent appointments for treatment and long-term follow-up can be challenging to achieve amongst a drug-using population with chaotic lives who often have unstable accommodation arrangements, and there are no specific guidelines to help practitioners manage this particular population. Of course, the life expectancy of an injecting drug user may be reduced, and therefore, the figures for long-term injectors and older injectors in this study need to be interpreted with caution due to reduced life span and bias as a result of early death [76].

Within the general population, women tend to develop leg ulceration more commonly than men [77, 75], and this increased prevalence is borne out within this study. It has been suggested, although not conclusively, that this is due to hormonal differences or longevity [78]. In drug injectors, it has been suggested that women’s veins become damaged and incompetent quicker than men as they tend to be smaller and thinner walled [79]. It may also be that women may tend to be more determined to hide the visual evidence of injecting and opt to inject in the groin which impacts on disease processes in the lower leg [6].

Femoral injecting may increase the risk of deep vein thrombosis due to repeated puncture, scarring and narrowing of the femoral vein [32], and one of the complications may be distal venous disease, including leg ulceration. In Glasgow, femoral injecting is relatively common and the link between using this site and the high rate of leg ulceration is worth exploring in the future.